Senior Scientist Translational Medicine -Immune Oncology and Cellular Therapy

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Immuno-Oncology and Cellular Therapy Thematic Research Center is one of the fundamental research and early development engines delivering therapeutics to patients. Our mission is to drive leadership in the use of immune effector cell-based therapies in hematological and solid cancers. More specifically, we are focused on developing engineered cell-based therapies, as well as biotherapeutics, both aimed at harnessing the power of immune cells to mediate anti-tumor activity. The team integrates discovery research seamlessly with preclinical sciences, translational research and early clinical development in collaboration with colleagues across the Research and Development organization. Our thematic focus allows the group to capitalize on the cutting edge science that underpins the action of many of the company’s most innovative therapeutics, without being constrained by drug modality or disease indication.

The candidate will have responsibility for directing the scientific aspects of drug development programs and translational medicine correlative studies in Immune Oncology and Cellular Therapy Thematic Research Center. The successful candidate will be responsible for driving and implementing translational development strategies for BMS’s drugs. Expertise in developing biomarkers for clinical trials, and strong knowledge in immunology and tumor biology, is required. The individual will work with contract research organizations, and internal and external collaborators, to design, execute, and interpret translationally focused experiments. Activities include biomarker identification, assay validation and implementation, and generation of data that supports patient stratification and pharmacodynamic evaluation of drugs and mechanism of action in the clinical trial setting. Candidates with experience in cellular therapies desirable.

Responsibilities:

In-depth knowledge of immunology, immune oncology, and tumor biology in solid and hematological malignancies

Develop new concepts and mechanism of action hypotheses identifying distinguishing characteristic of BMS IO and cell therapy agents alone and in combination with other therapies by utilizing translational medicine-based approaches.

Biomarker discovery and development: assay development/validation, discovery of biomarkers for clinical trial use, MoA research, knowledge of platforms

Manage internal projects in immune oncology and cell therapy drug development

Serve on internal cross functional project teams and committees as scientific functional lead

Work closely with corporate partners to support preclinical, translational and clinical development of cancer therapeutics.

Understand the context, impact and timely communication of data

Coordination of external academic collaborations and contract research laboratories

Specific Duties:

Develop and direct in-vitro and ex-vivo assays to translate preclinical data into meaningful clinical biomarkers for advancing drug candidates through clinical trials

Coordinate analysis of clinical trial samples and drive interpretation of pharmacodynamic and MoA biomarkers

Critically analyze, interpret, report experimental results; draw appropriate conclusions and design next steps

Participate in project and program team meetings to present data and provide interpretation

Establish and maintain working relationship with contract laboratories and relevant academic collaborators

Ensure that the Immune Oncology group maintains current awareness in area of expertise, and enhance the scientific credibility of BMS through contributions to the scientific literature (publications/presentations)

Contribute to the writing of investigator brochures, IND/BLA/MAA applications, regulatory annual reports, clinical trial protocols, and other regulatory documents when appropriate

Qualifications:

Degree in immunology, tumor biology or molecular or cellular biology, Ph.D. degree with at least 3 years of successful post-doctoral experience, plus a minimum of 6 years successful experience as a scientist preferably in the biotechnology or pharmaceutical industry setting

Expertise in developing and analyzing biomarkers for clinical trialsdesired

Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, immunocytochemistry, microscopy), and molecular biology

Excellent communication and interpersonal skills, evidenced by strong ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors

Detail-oriented with the ability to identify and implement creative solutions

Ability to prioritize and manage time efficiently

Ability to work effectively and collaboratively in a highly matrixed organization

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

Bristol-Myers Squibb Company
Website : http://www.bms.com