Senior Research Investigator Statistical Genetics

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Overview of position

We seek a talented scientist to combine human genetics and functional omics to enable the development of new therapeutics in partnership with the Immunology, Fibrosis, and Cardiovascular Thematic Research Center (ICF TRC). In this role, the successful candidate will design and apply computational pipelines to form in silico therapeutic hypotheses, which will inform the development of early discovery plans for novel targets. A key focus of this role will be to design and execute integrative analyses that realize the dual promise of large genetic studies of disease risk/progression and the power of emerging technologies for molecular profiling (e.g. single cell omics).

The successful candidate will be an important member of Target Sciences. Our team is part of the broader Immunology and Immune-Oncology Predictive Sciences Group, within the globally-distributed Informatics & Predictive Sciences (IPS) department. This department is involved in collaborative bioinformatics, computational biology, and patient selection research alongside colleagues in the Research & Early Development (R/ED) organization.

The position offers an exciting opportunity to make a difference in lives of patients, gain industry experience, and interact with the broader scientific community through multi-partner collaborations (e.g. Open Targets, FinnGen). The successful candidate will also be encouraged to publish their work and to present at external meetings and conferences.

Responsibilities

Design and perform integrative analyses that combine human genetics with single-cell RNAseq, ATACseq, and other omics data.

Identify novel therapeutic hypotheses (targets, cell types, pathways) for indications of interest in Immunology, Fibrosis, and Cardiovascular diseases.

Provide data-driven input on experimental design for target validation efforts (e.g. relevant cell types, assay read-outs, and/or appropriate genetic perturbations).

Work with external partners in academia and industry to collect functional data and develop integrative methods to empower future discovery efforts in ICF.

Participate in and oversight of scientific report writing. Presentation of methods, results and conclusions to a publishable standard.

Background experience & complementary knowledge

A Ph.D. in genomics, genetics, bioinformatics, or a related field from a recognized higher-education establishment.

Experience with relevant programming/scripting tools (e.g. R, Python, C/C ).

Expertise in analysis of functional genomics data, especially experience with single-cell RNAseq and epigenetic data (ATACseq, CHIPseq, etc).

Expertise in statistical genetics, especially experience with GWAS or QTL mapping. Experience with ‘post-GWAS’ integrative analyses (e.g. Mendelian randomization) a plus.

Knowledge and/or interests in immunology, cardiovascular, or fibrosis biology is preferable.

Experience in the pharmaceutical industry or otherwise with drug development is preferable.

Demonstrated ability to build strong working relationships that facilitate effective collaboration across cross-functional teams.

Track record of excellent interpersonal and communication skills, including ability to provide concise summaries of complex data to empower decision making.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

Bristol-Myers Squibb Company
Website : http://www.bms.com