Research Scientist Cell-based Assays

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Summary: The Biochemistry, Cell Biology and Molecular Pharmacology group in Cambridge is dedicated to working closely with chemistry colleagues in discovering novel small molecule therapeutics for immunological & neurological diseases and overcoming cancer resistance. Our primary role is to develop and apply robust biochemical and cell biology tools that enable small molecule drug discovery. These critical components of the drug discovery process provide in vitro data that guide early discovery and underpin their performance in preclinical disease settings. The data generated ultimately allows selection of drug candidates and forms an essential element in IND filings with the FDA for clinical development.

Description: This position will be responsible for developing and performing cell-based assays to enable oncology drug discovery programs. The candidate will collect, analyze and be responsible for effectively communicating assay results to project teams. The candidate should have strong assay development skills and working knowledge of cellular signaling with solid skills in cell culture techniques, including experience handling primary cells and ex vivo samples for assay execution.

Duties/Responsibilities:

Collaborate with colleagues across R&D to develop high-quality cell-based assays

Adapt these assays for high-throughput formats

Execute routine cell-based screening assays to ensure rapid and high-quality data delivery

Analyze, interpret and effectively report data at team meetings

Troubleshoot assays to ensure high quality control

Interface closely with disease biology colleagues to ensure assays and screening efforts are aligned to the scientific project goals

Lead efforts to identify, evaluate, and implement new technologies and methods that push the boundaries of complex cell-based screening

Interface with Informatics and automation colleagues proactively to drive the evolution of screening platforms and ensure adequate maintenance of the cell-based assay infrastructure

Key Experiences and qualities :

Demonstrated hands-on experience in developing various functional cell-based signaling assays in recombinant and primary cells

Practical expertise with high throughput screening using automated platforms and processes

Expertise in databases, data analysis & analytics and specialized analysis tools is required

Experience w automated liquid handlers, plate readers, software and robotics preferred

High content image screening and flow cytometry platforms experience is a plus

Self-motivated and a proven ability to work in a multifunctional team setting

Detail-oriented, highly organized with the ability to run multiple interleafed projects

Excellent interpersonal and communication skills

Ability and desire to master new skills, methods and technologies that enhance departmental capabilities

Qualifications

BS or Master's degree in biochemistry, pharmacology, cell biology or related field

3-5 years relevant research experience in assay development & execution, preferably in drug discovery

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1524811_EN

Updated: 2020-05-29 00:00:00.000 UTC

Location: Cambridge,Massachusetts

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

Company info

Bristol-Myers Squibb Company
Website : http://www.bms.com